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Article

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity.

Pharmacogenetics - 1 Nov 2000

Pirmohamed M, Alfirevic A, Vilar J, Stalford A, Wilkins E G, Sim E, Park B K

Abstract excerpt

The use of co-trimoxazole in HIV-positive patients has been associated with a high frequency (40-80%) of hypersensitivity reactions. This has been attributed to the bioactivation of the sulphonamide component, sulphamethoxazole (SMX), to its toxic hydroxylamine and nitroso metabolites. The aim of this study was to determine whether functionally significant polymorphisms in the genes coding for enzymes involved in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Trimethoprim, Sulfamethoxazole Drug Combination

Source

Identifiers

PMID: 11186133
DOI: 10.1097/00008571-200011000-00005

Genes

GSTM1
GSTP1
GSTT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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