Article

Genetic Variation at the Catalytic Subunit of Glutamate Cysteine Ligase Contributes to the Susceptibility to Colorectal Cancer: A Pilot Study

2022-01-27

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> Glutathione is a tripeptide detoxifying a variety of exogenous and endogenous free radicals and carcinogens, and a deficiency of glutathione is associated with an increased host susceptibility to oxidative stress, a pathological condition implicated in the development and progression of cancer. Catalytic subunit of glutamate-cysteine ligase (GCLС) is enzyme resp...

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Literature Corpus work: c5313d7a-b049-5678-a16c-dc7840cdcbb5
DOI: 10.21203/rs.3.rs-1253021/v1

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