Article
Multicenter study of trimethoprim/sulfamethoxazole-related hepatotoxicity: incidence and associated factors among HIV-infected patients treated for Pneumocystis jirovecii pneumonia.
PloS one - 1 Jan 2014
Yang Jen-Jia, Huang Chung-Hao, Liu Chun-Eng, Tang Hung-Jen, Yang Chia-Jui, Lee Yi-Chien, Lee Kuan-Yeh, Tsai Mao-Song, Lin Shu-Wen, Chen Yen-Hsu, Lu Po-Liang, Hung Chien-Ching
Abstract excerpt
The incidence of hepatotoxicity related to trimethoprim/sulfamethoxazole (TMP/SMX) administered at a therapeutic dose may vary among study populations of different ethnicities and hepatotoxic metabolites of TMP/SMX may be decreased by drug-drug interaction with fluconazole. We aimed to investigate the incidence of hepatotoxicity and the role of concomitant use of fluconazole in HIV-infected patients receiving...
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