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Article

TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.

Pharmacogenomics - 1 Apr 2009

Alfirevic Ana, Vilar F Javier, Alsbou Mohammed, Jawaid Ansar, Thomson Wendy, Ollier William E R, Bowman Clive E, Delrieu Olivier, Park B Kevin, Pirmohamed Munir

Abstract excerpt

AIMS: Sulfamethoxazole in combination with trimethoprim (cotrimoxazole) is used for prophylaxis and treatment of several opportunistic infections in HIV-infected patients. It is associated with a high incidence of hypersensitivity reactions, which is thought to have an immune basis. Genetic polymorphisms in MHC are known to predispose to hypersensitivity reactions to a structurally diverse group of drugs in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Trimethoprim, Sulfamethoxazole Drug Combination

Source

Identifiers

PMID: 19374512
DOI: 10.2217/pgs.09.6

Genes

LTA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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