Article
Allelic-Specific Regulation of xCT Expression Increases Susceptibility to Tuberculosis by Modulating microRNA-mRNA Interactions.
mSphere - 22 Apr 2020
Wang Wenfei, Cai Yi, Deng Guofang, Yang Qianting, Tang Peijun, Wu Meiying, Yu Ziqi, Yang Fan, Chen Jianyong, Werz Oliver, Chen Xinchun
Abstract excerpt
xCT forms part of the xc- cysteine-glutamate antiporter which inhibits antimicrobial inflammatory immune functions and thus increases susceptibility to tuberculosis (TB). However, the associations between xCT gene polymorphisms and susceptibility to TB, as well as whether these modulate xCT expression or affect treatment with the xCT inhibitor sulfasalazine (SASP), are unclear. In the present study, we genotyped...
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