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Article

An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro.

Molecular genetics and metabolism - 1 Sept 2010

Le Truc M, Willis Alecia S, Barr Frederick E, Cunningham Gary R, Canter Jeffrey A, Owens Sarah E, Apple Rachel K, Ayodo George, Reich David, Summar Marshall L

Abstract excerpt

Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of glutamate-cysteine ligase (GCLC), the rate-limiting enzyme in glutathione biosynth...

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Identifiers

PMID: 20655259
DOI: 10.1016/j.ymgme.2010.05.013
PMCID: PMC2922432

Genes

GCLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20655259-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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