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Article

Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.

American journal of human genetics - 1 Sept 2006

Tosic Mirjana, Ott Jurg, Barral Sandra, Bovet Pierre, Deppen Patricia, Gheorghita Fulvia, Matthey Marie-Louise, Parnas Josef, Preisig Martin, Saraga Michael, Solida Alessandra, Timm Sally, Wang August G, Werge Thomas, Cuénod Michel, Do Kim Quang

Abstract excerpt

Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene...

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Identifiers

PMID: 16909399
DOI: 10.1086/507566
PMCID: PMC1559555

Genes

GCLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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