Article
Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes.
BMC nephrology - 19 Jul 2012
El-Meanawy Ashraf, Schelling Jeffery R, Iyengar Sudha K, Hayden Patrick, Barathan Shrinath, Goddard Katrina, Pozuelo Fatima, Elashi Essam, Nair Viji, Kretzler Matthias, Sedor John R
Abstract excerpt
BACKGROUND: The genetic architecture responsible for chronic kidney disease (CKD) remains incompletely described. The Oligosyndactyly (Os) mouse models focal and segmental glomerulosclerosis (FSGS), which is associated with reduced nephron number caused by the Os mutation. The Os mutation leads to FSGS in multiple strains including the ROP-Os/+. However, on the C57Bl/6J background the mutation does not cause...
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