Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.

Journal of the American Society of Nephrology : JASN - 1 Dec 2015

Randles Michael J, Woolf Adrian S, Huang Jennifer L, Byron Adam, Humphries Jonathan D, Price Karen L, Kolatsi-Joannou Maria, Collinson Sophie, Denny Thomas, Knight David, Mironov Aleksandr, Starborg Toby, Korstanje Ron, Humphries Martin J, Long David A, Lennon Rachel

Abstract excerpt

Glomerular disease often features altered histologic patterns of extracellular matrix (ECM). Despite this, the potential complexities of the glomerular ECM in both health and disease are poorly understood. To explore whether genetic background and sex determine glomerular ECM composition, we investigated two mouse strains, FVB and B6, using RNA microarrays of isolated glomeruli combined with proteomic glomerular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albuminuria
Share to Cyclin-Dependent Kinase 5

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glomerular Basement Membrane

Share to Kidney Glomerulus

Share to Liver X Receptors

Share to Matrix Metalloproteinases

Share to Orphan Nuclear Receptors

Share to Tenascin

Source

Open in PubMed Open full text

Identifiers

PMID: 25896609
DOI: 10.1681/ASN.2014040419
PMCID: PMC4657824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.PMID 25896609Read ↗

Albuminuria is associated with too few glomeruli and too much testosterone.Semantic proximity Read ↗

Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes.Semantic proximity Read ↗

Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel Multiparent Mouse Model.Semantic proximity Read ↗

An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex PathogenesisSemantic proximity Read ↗

Genetic Modifiers of Mendelian Monogenic Collagen IV Nephropathies in Humans and MiceSemantic proximity Read ↗

A Comparative Presentation of Mouse Models That Recapitulate Most Features of Alport Syndrome.Semantic proximity Read ↗

Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism.Semantic proximity Read ↗

Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis.Semantic proximity Read ↗

Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespanSemantic proximity Read ↗

Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background.Semantic proximity Read ↗

Characterization of Matricellular Protein Expression Signatures in Mechanistically Diverse Mouse Models of Kidney InjurySemantic proximity Read ↗

Regulation of protein abundance in genetically diverse mouse populationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.