Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The spatially resolved transcriptome signatures of glomeruli in chronic kidney disease

22 Mar 2024

Abstract excerpt

Here, we used digital spatial profiling (DSP) to describe the glomerular transcriptomic signatures that may characterize the complex molecular mechanisms underlying progressive kidney disease in Alport syndrome, focal segmental glomerulosclerosis, and membranous nephropathy. Our results revealed significant transcriptional heterogeneity among diseased glomeruli, and this analysis showed that histologically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Renal and related cancers
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38516889
DOI: 10.1172/jci.insight.165515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The spatially resolved transcriptome signatures of glomeruli in chronic kidney diseasePMID 38516889Read ↗

Identification of conserved gene expression changes across common glomerular diseases by spatial transcriptomicsSemantic proximity Read ↗

Digital Spatial Profiling of Collapsing GlomerulopathySemantic proximity Read ↗

Spatially resolved transcriptome profiles of mammalian kidneys illustrate the molecular complexity of functional nephron segments, cell-to-cell interactions and genetic variantsSemantic proximity Read ↗

Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progressionSemantic proximity Read ↗

Detailed Quantification of Glomerular Structural Lesions Associates with Clinical Outcomes and Transcriptomic Profiles in Nephrotic SyndromeSemantic proximity Read ↗

A functional landscape of chronic kidney disease entities from public transcriptomic dataSemantic proximity Read ↗

Multi-Omics Mapping of Human Kidney Reveals Complement-Mediated Cellular Dynamics During Progression of Focal Segmental GlomerulosclerosisSemantic proximity Read ↗

Multi-Omics Mapping of Human Kidney Reveals Complement-Mediated Cellular Dynamics During Progression of Focal Segmental GlomerulosclerosisSemantic proximity Read ↗

Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cellsSemantic proximity Read ↗

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritisSemantic proximity Read ↗

Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli.Semantic proximity Read ↗

Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruliSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.