Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury

Abstract excerpt

Significance Statement Single-cell transcriptomics techniques have revolutionized the ability to characterize cells from heterogeneous organs like the kidney. Although glomerular disorders are an important cause of CKD, a thorough characterization of the cells in the glomerulus has remained challenging due to the technical difficulties of isolating undamaged cells, especially from glomeruli of diseased animals....

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