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Article

Transcriptional regulation of CYP2C19 and its role in altered enzyme activity.

Current drug metabolism - 1 Oct 2012

Uppugunduri Chakradhara Rao S, Daali Youssef, Desmeules Jules, Dayer Pierre, Krajinovic Maja, Ansari Marc

Abstract excerpt

Cytochrome P450 2C19 (CYP2C19) is involved in the metabolism of several drugs that are currently in clinical use. The gene encoding CYP2C19 is polymorphic with the existence of different alleles resulting in altered enzyme activity. In addition, CYP2C19 activity is also dependent on its basal expression levels determined by the transcriptional regulation. Genetic variations located in the CYP2C19 promoter region...

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Share to Aryl Hydrocarbon Hydroxylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22804232
DOI: 10.2174/138920012802850146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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