Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory polymorphisms in CYP2C19 affecting hepatic expression.

Drug metabolism and drug interactions - 1 Jan 2013

Sanford Jonathan C, Guo Yingying, Sadee Wolfgang, Wang Danxin

Abstract excerpt

BACKGROUND: Cytochrome P450 2C19 is responsible for the metabolism of many drugs, including the activation of clopidogrel. The allele CYP2C19*17 is associated with ultra-rapid metabolizer phenotypes by increasing gene transcription. This study tests to what extent CYP2C19*17 enhances CYP2C19 expression in human liver and whether additional regulatory variants contribute to variation in CYP2C19 expression....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Aryl Hydrocarbon Hydroxylases
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Gene Expression Regulation, Enzymologic

Share to Real-Time Polymerase Chain Reaction

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 23412869
DOI: 10.1515/dmdi-2012-0038
PMCID: PMC3755489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory polymorphisms in CYP2C19 affecting hepatic expression.PMID 23412869Read ↗

The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles.Semantic proximity Read ↗

Transcriptional regulation of CYP2C19 and its role in altered enzyme activity.Semantic proximity Read ↗

Genetic variability of CYP2C19 in a Mexican population: contribution to the knowledge of the inheritance pattern of CYP2C19*17 to develop the ultrarapid metabolizer phenotype.Semantic proximity Read ↗

Clinical Application of CYP2C19 Pharmacogenetics Toward More Personalized MedicineSemantic proximity Read ↗

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.Semantic proximity Read ↗

Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17.Semantic proximity Read ↗

Characterization of CYP2C19 pharmacogenetic variation in African populations and comparison with other global populations.Semantic proximity Read ↗

Mechanistic insights into the CYP2C19 genetic variants prevalent in the Indian population.Semantic proximity Read ↗

An allele-specific PCR system for rapid detection and discrimination of the CYP2C19∗4A, ∗4B, and ∗17 alleles: implications for clopidogrel response testing.Semantic proximity Read ↗

Testing for variants in CYP2C19: population frequencies and testing experience in a clinical laboratory.Semantic proximity Read ↗

Impact of CYP2C19 Gene Variants on Long-Term Treatment with Atorvastatin in Patients with Acute Coronary Syndromes.Semantic proximity Read ↗

Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.