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Involvement of hepatocyte nuclear factor 4alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2006

Kawashima Sachiyo, Kobayashi Kaoru, Takama Kaori, Higuchi Tomoaki, Furihata Tomomi, Hosokawa Masakiyo, Chiba Kan

Abstract excerpt

CYP2C9 and CYP2C19 are clinically important drug-metabolizing enzymes. The expression level of CYP2C9 is much higher than that of CYP2C19, although the factor(s) responsible for the difference between the expression levels of these genes is still unclear. It has been reported that hepatocyte nuclear factor 4alpha (HNF4alpha) plays an important role in regulation of the expression of liver-enriched genes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electrophoretic Mobility Shift Assay

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Share to Repetitive Sequences, Nucleic Acid

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PMID: 16540586
DOI: 10.1124/dmd.106.009365

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