Article
New insights into the regulation of CYP2C9 gene expression: the role of the transcription factor GATA-4.
Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2010
Mwinyi Jessica, Nekvindová Jana, Cavaco Isa, Hofmann Yvonne, Pedersen Rasmus Steen, Landman Ellie, Mkrtchian Souren, Ingelman-Sundberg Magnus
Abstract excerpt
CYP2C9 is an important drug-metabolizing enzyme that metabolizes, e.g., warfarin, antidiabetics, and antiphlogistics. However, the endogenous regulation of this enzyme is largely unknown. In this study, we examined the role of GATA transcription factors in the gene expression of CYP2C9. We investigated four putative GATA binding sites within the first 200 base pairs of CYP2C9 promoter at the positions I:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.