Article
Genetic variations and haplotypes of the 5' regulatory region of CYP2C19 in South Indian population.
Drug metabolism and pharmacokinetics - 1 Jan 2009
Satyanarayana Chakradhara Rao Uppugunduri, Devendran Anichavezhi, Sundaram Rajan, Gopal Shewade Deepak, Rajagopal Krishnamoorthy, Chandrasekaran Adithan
Abstract excerpt
CYP2C19 is expressed polymorphically with about 21 variant alleles. Genotype-phenotype association studies of CYP2C19 have shown marked deviations, suggesting the presence of other variations in the intronic and 5' regulatory region affecting its expression. This study aims to identify the genetic polymorphisms and construction of haplotypes of variations in 5' regulatory region of CYP2C19 among the South Indian...
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