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Article

The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.

Life sciences - 8 May 2010

Mwinyi Jessica, Hofmann Yvonne, Pedersen Rasmus Steen, Nekvindová Jana, Cavaco Isa, Mkrtchian Souren, Ingelman-Sundberg Magnus

Abstract excerpt

AIMS: Cytochrome P4502C19 (CYP2C19) is an important enzyme involved in the metabolism of antiulcer drugs and antidepressants. However, despite the well documented drug-dependent variability of CYP2C19 expression, the mechanisms underlying the regulation of the enzyme remain unknown. In this study...

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Source

Identifiers

PMID: 20206639
DOI: 10.1016/j.lfs.2010.02.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20206639-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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