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Article

The Transcriptional Regulation of the Human CYP2C Genes

1 Jul 2009

Abstract excerpt

In humans, four members of the CYP2C subfamily (CYP2C8, CYP2C9, CYP2C18, and CYP2C19) metabolize more than 20% of all therapeutic drugs as well as a number of endogenous compounds. The CYP2C enzymes are found predominantly in the liver, where they comprise approximately 20% of the total cytochrome P450. A variety of xenobiotics such as phenobarbital, rifampicin, and hyperforin have been shown to induce the...

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PMID: 19702536
DOI: 10.2174/138920009789375397

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