Alzheimer risk variant CLU and brain function during aging.

doi:10.1016/j.biopsych.2012.05.026

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Article

Alzheimer risk variant CLU and brain function during aging.

Biological psychiatry - 1 Mar 2013

Thambisetty Madhav, Beason-Held Lori L, An Yang, Kraut Michael, Nalls Michael, Hernandez Dena G, Singleton Andrew B, Zonderman Alan B, Ferrucci Luigi, Lovestone Simon, Resnick Susan M

Abstract excerpt

BACKGROUND: We examined the effect of the novel Alzheimer's disease (AD) risk variant rs11136000 single nucleotide polymorphism in the clusterin gene (CLU) on longitudinal changes in resting state regional cerebral blood flow (rCBF) during normal aging and investigated its influence on cognitive decline in presymptomatic stages of disease progression. METHODS: Subjects were participants in the Baltimore...

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PMID: 22795969
DOI: 10.1016/j.biopsych.2012.05.026
PMCID: PMC3488132

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