Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene.

doi:10.1016/j.euroneuro.2011.02.001

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Article

Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Dec 2011

Lancaster Thomas M, Baird Alison, Wolf Claudia, Jackson Margaret C, Johnston Stephen J, Donev Rossen, Thome Johannes, Linden David E J

Abstract excerpt

Recent GWAS identified a risk variant for Alzheimer's disease (AD) at a locus (rs11136000) of the clusterin gene (CLU). Here we use functional magnetic resonance imaging (fMRI) during working memory to probe the effect of the risk variant on brain activation in healthy individuals. Participants with the CLU risk genotype had higher activity than participants with the protective allele in frontal and posterior...

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PMID: 21397462
DOI: 10.1016/j.euroneuro.2011.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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