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Article

Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study.

The American journal of psychiatry - 1 Sept 2012

Sweet Robert A, Seltman Howard, Emanuel James E, Lopez Oscar L, Becker James T, Bis Joshua C, Weamer Elise A, DeMichele-Sweet Mary Ann A, Kuller Lewis H

Abstract excerpt

OBJECTIVE: The trajectory of cognitive decline in patients with late-onset Alzheimer's disease varies widely. Genetic variations in CLU, PICALM, and CR1 are associated with Alzheimer's disease, but it is unknown whether they exert their effects by altering cognitive trajectory in elderly individuals at risk for the disease. METHOD: The authors developed a Bayesian model to fit cognitive trajectories in a cohort...

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Source

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Identifiers

PMID: 22952074
DOI: 10.1176/appi.ajp.2012.11121815
PMCID: PMC3610571

Genes

CLU
PICALM
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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