Article
A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies.
Atherosclerosis - 1 Aug 2012
Brautbar Ariel, Pompeii Lisa A, Dehghan Abbas, Ngwa Julius S, Nambi Vijay, Virani Salim S, Rivadeneira Fernando, Uitterlinden André G, Hofman Albert, Witteman Jacqueline C M, Pencina Michael J, Folsom Aaron R, Cupples L Adrienne, Ballantyne Christie M, Boerwinkle Eric
Abstract excerpt
OBJECTIVE: Multiple studies have identified single-nucleotide polymorphisms (SNPs) that are associated with coronary heart disease (CHD). We examined whether SNPs selected based on predefined criteria will improve CHD risk prediction when added to traditional risk factors (TRFs). METHODS: SNPs were selected from the literature based on association with CHD, lack of association with a known CHD risk factor, and...
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