Article
Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study.
American journal of epidemiology - 1 Jul 2007
Morrison Alanna C, Bare Lance A, Chambless Lloyd E, Ellis Stephen G, Malloy Mary, Kane John P, Pankow James S, Devlin James J, Willerson James T, Boerwinkle Eric
Abstract excerpt
Recent studies have evaluated whether incorporating nontraditional risk factors improves coronary heart disease (CHD) prediction models. This 1986-2001 US study aggregated the contribution of multiple single nucleotide polymorphisms into a genetic risk score (GRS) and assessed whether the GRS plus traditional risk factors predict CHD better than traditional risk factors alone. The Atherosclerosis Risk in...
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