Article
Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities study.
Circulation. Cardiovascular genetics - 1 Jun 2009
Brautbar Ariel, Ballantyne Christie M, Lawson Kim, Nambi Vijay, Chambless Lloyd, Folsom Aaron R, Willerson James T, Boerwinkle Eric
Abstract excerpt
BACKGROUND: A single-nucleotide polymorphism on chromosome 9p21, rs10757274 (9p21 allele), has been shown to predict coronary heart disease (CHD) in whites. We evaluated whether adding the 9p21 allele to traditional risk factors (RFs) improved CHD risk prediction in whites from the Atherosclerosi...
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