Article
Identification of a late onset Alzheimer's disease candidate risk variant at 9q21.33 in Polish patients.
Journal of Alzheimer's disease : JAD - 1 Jan 2012
Gaj Pawel, Paziewska Agnieszka, Bik Wojciech, Dąbrowska Michalina, Baranowska-Bik Agnieszka, Styczynska Maria, Chodakowska-Żebrowska Małgorzata, Pfeffer-Baczuk Anna, Barcikowska Maria, Baranowska Boguslawa, Ostrowski Jerzy
Abstract excerpt
Late onset Alzheimer's disease (LOAD) accounts for about 95% of all Alzheimer's disease cases. While the APOE ε4 variant seems to have unparalleled influence on increased LOAD risk, it does not explain all of the heritability of LOAD. In this study, we present the application of a cost-effective, pooled DNA genome-wide association study (GWAS) to uncover genetic risk variants associated with LOAD in Polish women...
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