Article
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.
American journal of human genetics - 1 Jan 2009
Beecham Gary W, Martin Eden R, Li Yi-Ju, Slifer Michael A, Gilbert John R, Haines Jonathan L, Pericak-Vance Margaret A
Abstract excerpt
Only Apolipoprotein E polymorphisms have been consistently associated with the risk of late-onset Alzheimer disease (LOAD), but they represent only a minority of the underlying genetic effect. To identify additional LOAD risk loci, we performed a genome-wide association study (GWAS) on 492 LOAD cases and 498 cognitive controls using Illumina's HumanHap550 beadchip. An additional 238 cases and 220 controls were...
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