Article
Extended kindred with recessive late-onset Alzheimer disease maps to locus 8p22-p21.2: a genome-wide linkage analysis.
Alzheimer disease and associated disorders - 1 Jan 2000
Baron Manuel, Gomez-Tortosa Estrella, Bochdanovits Zoltan, Gobernado Isabel, Rabano Alberto, Munoz David G, Heutink Peter, Jimenez-Escrig Adriano
Abstract excerpt
Late-onset Alzheimer disease (LOAD) is a complex genetic disorder. Although genes involved in early-onset forms were discovered more than a decade ago, LOAD research has only been able to point out small effect loci, with the exception of APOE. We mapped the gene predisposing to LOAD in an extended inbred family coming from a genetically isolated region (24 sampled individuals, 12 of whom are affected),...
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