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Article

Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons.

Genes, brain, and behavior - 1 Oct 2012

Johnson C, Chun-Jen Lin C, Stern M

Abstract excerpt

The lipid kinase PI3K plays key roles in cellular responses to activation of receptor tyrosine kinases or G protein coupled receptors such as the metabotropic glutamate receptor (mGluR). Activation of the PI3K catalytic subunit p110 occurs when the PI3K regulatory subunit p85 binds to phosphotyrosine residues present in upstream activating proteins. In addition, Ras is uniquely capable of activating PI3K in a...

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Identifiers

PMID: 22783951
DOI: 10.1111/j.1601-183X.2012.00822.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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