Article
Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways.
Molecular and cellular biology - 1 Jan 2004
MacDougall Lindsay K, Gagou Mary Elizabeth, Leevers Sally J, Hafen Ernst, Waterfield Michael D
Abstract excerpt
Phosphoinositide 3-kinases (PI3Ks) can be divided into three distinct classes (I, II, and III) on the basis of their domain structures and the lipid signals that they generate. Functions have been assigned to the class I and class III enzymes but have not been established for the class II PI3Ks. We have obtained the first evidence for a biological function for a class II PI3K by expressing this enzyme during...
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