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Article

Signalling by PI3K isoforms: insights from gene-targeted mice.

Trends in biochemical sciences - 1 Apr 2005

Vanhaesebroeck Bart, Ali Khaled, Bilancio Antonio, Geering Barbara, Foukas Lazaros C

Abstract excerpt

Phosphoinositide 3-kinases (PI3Ks) generate lipids that control a wide variety of intracellular signalling pathways. Part of this diversity in PI3K actions stems from the broad range of protein effectors of the PI3K lipids. A further layer of complexity is added by the existence of multiple isoforms of PI3K. Gene-targeting studies in the mouse have recently uncovered key roles for specific PI3K isoforms in...

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Identifiers

PMID: 15817396
DOI: 10.1016/j.tibs.2005.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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