Article
Input from Ras is required for maximal PI(3)K signalling in Drosophila.
Nature cell biology - 1 Nov 2006
Orme Mariam H, Alrubaie Saif, Bradley Gemma L, Walker Cherryl D, Leevers Sally J
Abstract excerpt
Class I phosphoinositide 3-kinases (PI(3)Ks) are activated through associated adaptor molecules in response to G protein-coupled and tyrosine kinase receptor signalling. They contain Ras-binding domains (RBDs) and can also be activated through direct association with active GTP-bound Ras. The ability of Ras to activate PI(3)K has been established in vitro and by overexpression analysis, but its relevance for...
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