Article
Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity.
Development (Cambridge, England) - 1 May 2001
Halfar K, Rommel C, Stocker H, Hafen E
Abstract excerpt
Ras mediates a plethora of cellular functions during development. In the developing eye of Drosophila, Ras performs three temporally separate functions. In dividing cells, it is required for growth but is not essential for cell cycle progression. In postmitotic cells, it promotes survival and subsequent differentiation of ommatidial cells. In the present paper, we have analyzed the different roles of Ras during...
Topics
- Animals
- Cell Cycle
- Cell Differentiation
- Cell Survival
- Drosophila
- Eye
- Mitogen-Activated Protein Kinases
- Models, Biological
- Mutation
- Photoreceptor Cells, Invertebrate
- Proto-Oncogene Proteins c-raf
- ras Proteins