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Article

A PI3-kinase-mediated negative feedback regulates neuronal excitability.

PLoS genetics - 1 Nov 2008

Howlett Eric, Lin Curtis Chun-Jen, Lavery William, Stern Michael

Abstract excerpt

Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to neurological pathologies, such as epilepsy, but the precise mechanisms by which this feedback can occur remain incompletely understood. At one glutamatergic synapse, the Drosophila neuromuscular...

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Identifiers

PMID: 19043547
DOI: 10.1371/journal.pgen.1000277
PMCID: PMC2581892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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