Article
fras1 shapes endodermal pouch 1 and stabilizes zebrafish pharyngeal skeletal development.
Development (Cambridge, England) - 1 Aug 2012
Talbot Jared Coffin, Walker Macie B, Carney Thomas J, Huycke Tyler R, Yan Yi-Lin, BreMiller Ruth A, Gai Linda, Delaurier April, Postlethwait John H, Hammerschmidt Matthias, Kimmel Charles B
Abstract excerpt
Lesions in the epithelially expressed human gene FRAS1 cause Fraser syndrome, a complex disease with variable symptoms, including facial deformities and conductive hearing loss. The developmental basis of facial defects in Fraser syndrome has not been elucidated. Here we show that zebrafish fras1 mutants exhibit defects in facial epithelia and facial skeleton. Specifically, fras1 mutants fail to generate a...
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