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Article

Pharyngeal morphogenesis requires fras1-itga8-dependent epithelial-mesenchymal interaction.

Developmental biology - 1 Aug 2016

Talbot Jared Coffin, Nichols James T, Yan Yi-Lin, Leonard Isaac F, BreMiller Ruth A, Amacher Sharon L, Postlethwait John H, Kimmel Charles B

Abstract excerpt

Both Fras1 and Itga8 connect mesenchymal cells to epithelia by way of an extracellular 'Fraser protein complex' that functions in signaling and adhesion; these proteins are vital to the development of several vertebrate organs. We previously found that zebrafish fras1 mutants have craniofacial defects, specifically, shortened symplectic cartilages and cartilage fusions that spare joint elements. During a forward...

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Identifiers

PMID: 27265864
DOI: 10.1016/j.ydbio.2016.05.035
PMCID: PMC4967372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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