Article
FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish.
American journal of human genetics - 11 Feb 2011
Ghassibe-Sabbagh Michella, Desmyter Laurence, Langenberg Tobias, Claes Filip, Boute Odile, Bayet Bénédicte, Pellerin Philippe, Hermans Karlien, Backx Liesbeth, Mansilla Maria Adela, Imoehl Sandra, Nowak Stefanie, Ludwig Kerstin U, Baluardo Carlotta, Ferrian Melissa, Mossey Peter A, Noethen Markus, Dewerchin Mieke, François Geneviève, Revencu Nicole, Vanwijck Romain, Hecht Jacqueline, Mangold Elisabeth, Murray Jeffrey, Rubini Michele, Vermeesch Joris R, Poirel Hélène A, Carmeliet Peter, Vikkula Miikka
Abstract excerpt
Cranial neural crest (CNC) is a multipotent migratory cell population that gives rise to most of the craniofacial bones. An intricate network mediates CNC formation, epithelial-mesenchymal transition, migration along distinct paths, and differentiation. Errors in these processes lead to craniofacial abnormalities, including cleft lip and palate. Clefts are the most common congenital craniofacial defects. Patients...
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