Article

The Fraser complex interconnects tissue layers to support basal epidermis and osteoblast integrated morphogenesis underlying fin skeletal patterning

2023-07-09

Abstract excerpt

<h4>ABSTRACT</h4> Fraser Syndrome is a rare, multisystemic autosomal recessive disorder characterized by disrupted epithelial-mesenchymal associations upon loss of Fraser Complex genes. Disease manifestation and affected organs are highly variable. Digit malformations such as syndactyly are common but of unclear developmental origins. We explored if zebrafish fraser extracellular matrix complex subunit 1 (fras1)...

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Literature Corpus work: 810184dc-3355-5c02-9ea5-05bb8a257742
DOI: 10.1101/2023.07.08.548238

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