Article
Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning.
Developmental biology - 1 Jul 2006
Walker Macie B, Miller Craig T, Coffin Talbot Jared, Stock David W, Kimmel Charles B
Abstract excerpt
Endothelin1 (Edn1) signaling promotes ventral character to the facial skeleton. In zebrafish edn1 mutants, the ventral jaw structures are severely reduced and fused to their dorsal counterparts, with a loss of joints that normally form at an intermediate dorsal-ventral position. Loss of function at another locus, sturgeon, also yields joint losses, but only mild reductions in the ventral jaw structures. We show...
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