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Article

An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates.

Development (Cambridge, England) - 23 Dec 2020

Carroll Shannon H, Macias Trevino Claudio, Li Edward B, Kawasaki Kenta, Myers Nikita, Hallett Shawn A, Alhazmi Nora, Cotney Justin, Carstens Russ P, Liao Eric C

Abstract excerpt

Irf6 and Esrp1 are important for palate development across vertebrates. In zebrafish, we found that irf6 regulates the expression of esrp1 We detailed overlapping Irf6 and Esrp1/2 expression in mouse orofacial epithelium. In zebrafish, irf6 and esrp1/2 share expression in periderm, frontonasal ectoderm and oral epithelium. Genetic disruption of irf6 and esrp1/2 in zebrafish resulted in cleft of the anterior...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33234718
DOI: 10.1242/dev.194498
PMCID: PMC7774891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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