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Article

Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production.

European journal of immunology - 1 Oct 2012

Landego Ivan, Jayachandran Nipun, Wullschleger Stephan, Zhang Ting-ting, Gibson Ian W, Miller Angela, Alessi Dario R, Marshall Aaron J

Abstract excerpt

TAPP1 and TAPP2 (where TAPP is tandem PH domain containing protein) are dual PH domain adaptors that selectively bind PI(3,4)P2 (phosphatidylinositol (3,4)-bisphosphate). PI(3,4)P2 is a lipid messenger generated by phosphoinositide 3-kinase (PI3K) and SHIP, both of which are critical regulators of B-cell activation. To determine the functional role of TAPP-PI(3,4)P2 interactions, we utilized a double knock-in...

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Source

Identifiers

PMID: 22777911
DOI: 10.1002/eji.201242371

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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