Article
Receptor Interacting Protein Kinase Pathways Regulate Innate B Cell Developmental Checkpoints But Not Effector Function in Mice.
Frontiers in immunology - 1 Jan 2021
Parthasarathy Raksha, Hägglöf Thomas, Hadley Jason T, McLennan Alexandra, Mattke Aiden, Dudley Elizabeth A, Kumagai Abigail, Dong Lily Q, Leadbetter Elizabeth A
Abstract excerpt
Mutations in the scaffolding domain of Receptor Interacting Protein kinases (RIP) underlie the recently described human autoimmune syndrome, CRIA, characterized by lymphadenopathy, splenomegaly, and autoantibody production. While disease mechanisms for CRIA remain undescribed, RIP kinases work together with caspase-8 to regulate cell death, which is critical for normal differentiation of many cell types. Here, we...
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