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Article

Spi-1 and Spi-B control the expression of the Grap2 gene in B cells.

Gene - 20 Jun 2005

Garrett-Sinha Lee Ann, Hou Ping, Wang Duncheng, Grabiner Brian, Araujo Elizabeth, Rao Sridhar, Yun Theodore J, Clark Edward A, Simon M Celeste, Clark Marcus R

Abstract excerpt

The Ets family members Spi-1 and Spi-B have been implicated in the regulation of genes important for B cell antigen receptor (BCR) signaling. Mice deficient in Spi-B exhibit reduced B cell proliferation in response to BCR cross-linking and impaired T cell-dependent immune responses. This defect is exacerbated in the presence of Spi-1 haplo-insufficiency (Spi1+/- SpiB-/-). Tyrosine phosphorylation and calcium...

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Source

Identifiers

PMID: 15936902
DOI: 10.1016/j.gene.2005.04.009

Genes

BCR
BLNK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spi-1 and Spi-B control the expression of the Grap2 gene in B cells.PMID 15936902Read ↗

Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability.Semantic proximity Read ↗

SPI-C, a PU-box binding ETS protein expressed temporarily during B-cell development and in macrophages, contains an acidic transactivation domain located to the N-terminus.Semantic proximity Read ↗

Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks β-SelectionSemantic proximity Read ↗

Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production.Semantic proximity Read ↗

Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.Semantic proximity Read ↗

Spi-B is critical for plasmacytoid dendritic cell function and development.Semantic proximity Read ↗

The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.Semantic proximity Read ↗

The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain.Semantic proximity Read ↗

BCR/ABL Directly Inhibits Expression of SHIP, an SH2-Containing Polyinositol-5-Phosphatase Involved in the Regulation of HematopoiesisSemantic proximity Read ↗

BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.Semantic proximity Read ↗

An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion.Semantic proximity Read ↗

Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development.Semantic proximity Read ↗

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