Article
Spi-1 and Spi-B control the expression of the Grap2 gene in B cells.
Gene - 20 Jun 2005
Garrett-Sinha Lee Ann, Hou Ping, Wang Duncheng, Grabiner Brian, Araujo Elizabeth, Rao Sridhar, Yun Theodore J, Clark Edward A, Simon M Celeste, Clark Marcus R
Abstract excerpt
The Ets family members Spi-1 and Spi-B have been implicated in the regulation of genes important for B cell antigen receptor (BCR) signaling. Mice deficient in Spi-B exhibit reduced B cell proliferation in response to BCR cross-linking and impaired T cell-dependent immune responses. This defect is exacerbated in the presence of Spi-1 haplo-insufficiency (Spi1+/- SpiB-/-). Tyrosine phosphorylation and calcium...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Blotting, Northern
- Blotting, Western
- Cell Line, Tumor
- DNA-Binding Proteins
- Down-Regulation