Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.

The EMBO journal - 16 Jul 1997

Miyazaki T, Müller U, Campbell K S

Abstract excerpt

CD81 (TAPA-1) is a member of the transmembrane 4 superfamily (TM4SF) which is expressed on the cell surface of most cells of the body throughout their cellular differentiation. It has been recognized in several cell surface complexes of lymphocytes, suggesting that it may have diverse roles in lymphocyte development and activation regulation. Mice with a CD81 null mutation revealed normal T- and conventional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Cell Division
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Membrane Proteins

Share to Mutation

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 9250665
DOI: 10.1093/emboj/16.14.4217
PMCID: PMC1170047

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.PMID 9250665Read ↗

A LAT mutation that inhibits T cell development yet induces lymphoproliferation.Semantic proximity Read ↗

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.Semantic proximity Read ↗

Increased brain size and glial cell number in CD81-null mice.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

Conditional deletion of SLP‐76 in mature T cells abrogates peripheral immune responsesSemantic proximity Read ↗

The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain.Semantic proximity Read ↗

The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.Semantic proximity Read ↗

Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT CellsSemantic proximity Read ↗

Weak SLP-76/PLC-γ1 interaction fine-tunes T cell receptor signal strength to optimize T cell responsiveness.Semantic proximity Read ↗

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.Semantic proximity Read ↗

T-cell Intracellular Antigen (TIA)-Proteins Deficiency in Murine Embryonic Fibroblasts Alters Cell Cycle Progression and Induces AutophagySemantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.