Article
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2016
Shim Hyeseok, Wu Chuan, Ramsamooj Shivan, Bosch Kaitlyn N, Chen Zuojia, Emerling Brooke M, Yun Jihye, Liu Hui, Choo-Wing Rayman, Yang Zhiwei, Wulf Gerburg M, Kuchroo Vijay Kumar, Cantley Lewis C
Abstract excerpt
Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three enzymes PI5P4Kα, PI5P4Kβ, and PI5P4Kγ, and these enzymes have been implicated in metabolic control, growth control, and a variety of stress responses. Here, we show that mice with germline deletion of type 2 phosphatidylinositol-5-phosphate 4-kinase gamma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.