Article
HLA alleles determine differences in human natural killer cell responsiveness and potency.
Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2008
Kim Sungjin, Sunwoo John B, Yang Liping, Choi Taewoong, Song Yun-Jeong, French Anthony R, Vlahiotis Anna, Piccirillo Jay F, Cella Marina, Colonna Marco, Mohanakumar Thalachallour, Hsu Katharine C, Dupont Bo, Yokoyama Wayne M
Abstract excerpt
Epidemiological studies have associated certain human disease outcomes with particular killer cell Ig-like receptor (KIR) and HLA genotypes. However, the functional explanation for these associations is poorly understood, because the KIRs were initially described as natural killer (NK) cell inhibitory receptors with specificity for HLA molecules on their cellular targets. Yet resolution of infections is often...
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