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Article

Multifactorial determinants of NK cell repertoire organization: insights into age, sex, KIR genotype, HLA typing, and CMV influence.

Frontiers in immunology - 1 Jan 2024

Ferron Enora, David Gaëlle, Willem Catherine, Legrand Nolwenn, Salameh Perla, Anquetil Laetitia, Walencik Alexandre, Gendzekhadze Ketevan, Gagne Katia, Retière Christelle

Abstract excerpt

Introduction: Polymorphisms in the KIR and HLA genes contribute to the diversity of the NK cell repertoire. Extrinsic factors also play a role in modifying this repertoire. The best example is cytomegalovirus, which promotes the expansion of memory-like NK cells. However, the mechanisms governing this phenotypic structure are poorly understood. Furthermore, the influence of age and sex has been understudied....

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Share to CD57 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Killer Cells, Natural

Share to NK Cell Lectin-Like Receptor Subfamily C

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Source

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Identifiers

PMID: 38736873
DOI: 10.3389/fimmu.2024.1389358
PMCID: PMC11082329

Genes

C2
KIR3DL1
KIR2DL1
KIR2DL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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