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Article

GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder.

Journal of affective disorders - 15 Dec 2012

Kishi Taro, Ichinose Hiroshi, Yoshimura Reiji, Fukuo Yasuhisa, Kitajima Tsuyoshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Musso Giovanna M, Umene-Nakano Wakako, Nakamura Jun, Ozaki Norio, Iwata Nakao

Abstract excerpt

BACKGROUND: Tetrahydrobiopterin (BH4) plays an important role in the biosynthesis of serotonin, melatonin and catecholamines, all of which are implicated in the pathophysiology of mood disorders (MDs), including major depressive disorder (MDD) and bipolar disorder (BP). Production of BH4 is regulated by GTP cyclohydrolase transcription and activity. Thus, we considered the GTP cyclohydrolase gene (GCH1) to be a...

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Identifiers

PMID: 22770721
DOI: 10.1016/j.jad.2012.05.004

Genes

GCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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