Functional polymorphism of the GTP cyclohydrolase 1 gene affects the personality trait of novelty seeking in healthy subjects.

doi:10.1016/j.neulet.2011.08.040

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Article

Functional polymorphism of the GTP cyclohydrolase 1 gene affects the personality trait of novelty seeking in healthy subjects.

Neuroscience letters - 10 Oct 2011

Sadahiro Ryoichi, Suzuki Akihito, Matsumoto Yoshihiko, Shibuya Naoshi, Enokido Masanori, Kamata Mitsuhiro, Goto Kaoru, Otani Koichi

Abstract excerpt

GTP cyclohydrolase 1 (GCH1) is the initial and rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, which is an essential cofactor for biosynthetic enzymes of dopamine, serotonin, and nitric oxide. In the present study, the association of functional polymorphism of the GCH1 gene (C+243T, rs841) with personality traits was examined in 902 healthy Japanese subjects. Personality traits were assessed by...

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PMID: 21896313
DOI: 10.1016/j.neulet.2011.08.040

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GCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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