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Article

Photocontrol of tyrosine phosphorylation in mammalian cells via genetic encoding of photocaged tyrosine.

Journal of the American Chemical Society - 25 Jul 2012

Arbely Eyal, Torres-Kolbus Jessica, Deiters Alexander, Chin Jason W

Abstract excerpt

We report the first site-specific genetic encoding of photocaged tyrosine into proteins in mammalian cells. By photocaging Tyr701 of STAT1 we demonstrate that it is possible to photocontrol tyrosine phosphorylation and signal transduction in mammalian cells.

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Source

Identifiers

PMID: 22758385
DOI: 10.1021/ja3046958

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22758385-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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