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Article

Control of protein phosphorylation with a genetically encoded photocaged amino acid.

Nature chemical biology - 1 Dec 2007

Lemke Edward A, Summerer Daniel, Geierstanger Bernhard H, Brittain Scott M, Schultz Peter G

Abstract excerpt

We genetically encoded the photocaged amino acid 4,5-dimethoxy-2-nitrobenzylserine (DMNB-Ser) in Saccharomyces cerevisiae in response to the amber nonsense codon TAG. This amino acid was converted to serine in living cells by irradiation with relatively low-energy blue light and was used to noninvasively photoactivate phosphorylation of the transcription factor Pho4, which controls the cellular response to...

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PMID: 17965709
DOI: 10.1038/nchembio.2007.44

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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